Temonat 100mg (Temozolomide)

TEMONAT 100MG CAPSULE contains Temozolomide, which belongs to the group of medicines called Antineoplastic agents. It is used for specific forms of brain tumours in adults with newly diagnosed glioblastoma multiforme, which is used first together with radiotherapy as a concomitant phase of therapy and then used alone as a monotherapy. It is also used in children (above 3 years) and adults to manage malignant gliomas, such as glioblastoma multiforme or anaplastic astrocytoma, if they return or get worse after standard management.

Glioblastoma multiforme is an aggressive type of cancer that affects the brain or spinal cord and is generally characterized by symptoms such as headache, nausea, drowsiness, blurred vision, personality changes, and seizures.

Along with this management, your doctor might advise you to take liver function tests to assess the hepatotoxicity and function of your liver. Before taking TEMONAT 100MG CAPSULE, inform your doctor if you have or ever had a hepatitis B infection (serious liver infection).

TEMONAT 100MG CAPSULE is not recommended for use if you have certain kinds of blood cells that are severely reduced, such as white blood cells and platelet count. TEMONAT 100MG CAPSULE should be used with caution during pregnancy only if it is clearly necessary and not recommended for use in breastfeeding women. It is not recommended for use in children below 3 years of age and should be used with caution in children and adolescents (from 3 to 18 years of age). Consult your doctor before taking TEMONAT 100MG CAPSULE. The most common side effects of taking TEMONAT 100MG CAPSULE are loss of appetite, difficulty while speaking, headache, vomiting, nausea, diarrhea, and constipation. Consult and inform your doctor if any of these symptoms get worse.

It is used for:

• Specific forms of brain tumours in newly diagnosed glioblastoma multiforme (in adults)
• Malignant glioma, such as glioblastoma multiforme or anaplastic astrocytoma (in adults and children)

TEMONAT 100MG CAPSULE works by damaging the genetic material (DNA and RNA) of the cancer cells inside the brain cells and works against the cell growth and multiplication.

Take TEMONAT 100MG CAPSULE as advised by your physician. Swallow TEMONAT 100MG CAPSULE with a glass of water and do not chew or crush the medicine. Your doctor will decide the correct dose and duration for you depending upon your age, body weight, and disease condition.

COMMON

• Loss of appetite
• Difficulty while speaking
• Headache
• Vomiting, nausea
• Diarrhea
• Constipation
• Rash
• Hair loss
• Tiredness
• Infections
• Feeling sick, extreme tiredness, loss of appetite (signs of neutropenia)
• Fever, cough, runny nose (signs of lymphopenia)
• Prolonged cuts, bleeding from gums, blood in urine (signs of thrombocytopenia)
• Allergic reactions
• Memory impairment
• Depression, anxiety, confusion, sleeplessness
• Difficulty concentrating
• Dizziness
• Visual disturbances
• Deafness, ringing in the ears, earache
• Blood clot in the lung or legs
• High blood pressure
• Shortness of breath
• Bronchitis
• Cough and cold
• Inflammation of sinuses
• Stomach or abdominal pain
• Dry skin, itching
• Muscle damage, muscle aches and pain, muscle weakness
• Joint and back pain
• Frequent urination
• Fever
• Flu-like symptoms such as chills, cough, fever, and muscle aches
• Pain
• Fluid retention
• Weight gain or loss
• Radiation injury such as weakness, hair loss, and bloody vomit

UNCOMMON

• New or reactivated cytomegalovirus infections such as chickenpox, herpes simplex
• Signs of reactivated hepatitis B virus infections such as abdominal pain, dark urine, fever, and joint pain
• Secondary cancers, including leukemia (blood cancer)
• Reduced blood cell counts, such as pancytopenia
• Red spots under the skin
• Signs of diabetes insipidus
• Piles
• Dry mouth
• Blisters on body or in mouth
• Skin peeling, skin eruption, painful reddening of the skin, severe rash with skin swelling
• Increased sensitivity to sunlight
• Urticaria (red, itchy skin)
• Increased sweating
• Change in skin colour
• Vaginal bleeding or irritation
• Absent or heavy menstrual periods
• Breast pain
• Sexual impotence
• Shivering

Stop taking TEMONAT 100MG CAPSULE and contact your doctor if you experience any of the following side effects: 

• Signs of a severe allergic (hypersensitive) reaction such as itchy red skin, wheezing, or other breathing difficulty
• Uncontrolled bleeding
• Seizures (fits)
• Fever and symptoms of infections such as cough, chills, sweat
• Chills
• Severe headache